Skip to main content

Hidden brain signals behind working memory

Making a specific type of brain pattern last longer improves short-term memory in rats, a new study finds.
Rats in maze
Published online by the journal Science on June 14, the study addressed "working memory," the temporary activation of brain cells that happens as we tour a new neighborhood, for instance, and remember our way around later that day.
Led by researchers at NYU School of Medicine, the new study finds that signals created by brain cells (neurons) -- called sharp wave ripples -- are longer by tens of milliseconds and capture more information when an animal is learning about a new place than when in a familiar setting.
When the research team artificially doubled the length of the signals involved in memory recall of the best route through a maze, rats with extended ripples were found to be 10-15 percent better at finding a sugary reward than rats without the manipulation.
"Our study is the first in our field that made artificial changes to intrinsic neuronal firing patterns in the brain region called the hippocampus that increased the ability to learn, instead of interfering with it like previous attempts," says György Buzsáki, MD, PhD, the Biggs Professor in the Department of Neuroscience and Physiology at NYU School of Medicine. "After decades of study, we finally understand the mammalian brain well enough to alter some of its mechanisms in ways that may guide the design of future treatments for diseases that affect memory."
The study results revolve around nerve cells, which "fire" -- or bring about quick swings in the balance of their positive and negative charges -- to transmit electrical signals that coordinate memories. Buzsáki's team in recent years discovered that sets of neurons fire within milliseconds of each other in rhythmic cycles -- creating closely connected sequences of signals that can encode complex information.
This observed pattern -- where hippocampal cells in different parts of the circuit fire together briefly -- creates "sharp wave ripples." The patterns are named for their shape when captured graphically by electro-encephalography or EEG, a technology that records brain activity with electrodes.
Buzsáki says the ripples represent the 'replaying' and combining of fragments of learned information, part of the process that weaves them into an animal's memory.
Within the Ripple
In the current study, the team designed experiments such that the correct route to get sugary water alternated between the left and right arms of a maze each time a rat was placed in it. To get their reward, the rats had to use working memory, recalling which way they had gone on the previous trial, and choosing the opposite way the next time.
Studies in recent years in many labs have established that hippocampal "place cells" encode each room, or each arm of a maze, when entered, and then fire again as rats or humans remember going there, or plan to go there again. The study authors recorded the firing of place cells as a rat performed the memory task in the maze, and predicted the route taken as reflected in the cell firing sequence captured in each sharp wave ripple.
To artificially double the duration of just the ripples made by rat's brain cells during task-driven navigation, researchers engineered hippocampal cells to include light-sensitive channels. Shining light through tiny glass fibers activated neurons, adding more neurons to the naturally occurring sequence, thereby encoding more detail of the maze representation.
Importantly, the study also found that the extended ripples enabled slower-firing neurons to be recruited into their sequences. The authors' past studies had shown these sluggish neurons to be better at changing their properties (more plastic) as something new is learned.
In contrast, faster firing partners in a ripple tended to start the sequence regardless of which route the rat took. Buzsáki's team has been building the case that such 'rigid' neurons generalize across experiences, encoding the familiar (instead of the newfound) aspects of each newly encountered location.
"Our next step will be to seek to understand how sharp wave ripples can be prolonged by non-invasive means, which if we succeed would have implications for treating memory disorders," says first author Antonio Fernandez-Ruiz, PhD, a postdoctoral fellow in Buzsáki's lab.
Along with Buzsáki and Fernandez-Ruiz, authors from the New York University Neuroscience Institute were first author Azahara Oliva, Eliezyer Fermino de Oliveira, Florbela Rocha- Almeida, and David Tingley.
This work was supported by the Sir Henry Wellcome Postdoctoral Fellowship, EMBO Postdoctoral Fellowship -ALTF 120-2017, FAPESP grant 2017/03729-2, National Institutes of Health grants MH107396, NS074015, and U19NS104590, and National Science Foundation grant 1707316.
Story Source:
Note: Content may be edited.

Comments

Post a Comment

Popular posts from this blog

Dark matter may be older than the Big Bang

Dark matter, which researchers believe make up about 80% of the universe's mass, is one of the most elusive mysteries in modern physics. What exactly it is and how it came to be is a mystery, but a new Johns Hopkins University study now suggests that dark matter may have existed before the Big Bang. The study, published August 7 in  Physical Review Letters , presents a new idea of how dark matter was born and how to identify it with astronomical observations. "The study revealed a new connection between particle physics and astronomy. If dark matter consists of new particles that were born before the Big Bang, they affect the way galaxies are distributed in the sky in a unique way. This connection may be used to reveal their identity and make conclusions about the times before the Big Bang too," says Tommi Tenkanen, a postdoctoral fellow in Physics and Astronomy at the Johns Hopkins University and the study's author. While not much is known about its origins,...
Post a Comment
Read more

Home births as safe as hospital births: International study suggests

A large international study led by McMaster University shows that low risk pregnant women who intend to give birth at home have no increased chance of the baby's perinatal or neonatal death compared to other low risk women who intend to give birth in a hospital. The results have been published by  The Lancet 's  EClinicalMedicine  journal. "More women in well-resourced countries are choosing birth at home, but concerns have persisted about their safety," said Eileen Hutton, professor emeritus of obstetrics and gynecology at McMaster, founding director of the McMaster Midwifery Research Centre and first author of the paper. "This research clearly demonstrates the risk is no different when the birth is intended to be at home or in hospital." The study examined the safety of place of birth by reporting on the risk of death at the time of birth or within the first four weeks, and found no clinically important or statistically different risk between home...
Post a Comment
Read more

GSAT-11 satellite to be launched from French Guiana on Dec 5th

GSAT-11 satellite to be launched from French Guiana on Dec 5th GSAT-11 would be located at 74 East and is the fore-runner in a series of advanced communications satellite with multi-spot beam antenna coverage over Indian mainland and Islands, ISRO said. GSAT-11 is the next generation “high throughput” communication satellite configured around ISRO’s I-6K Bus. (PTI/Representational). Indian space agency ISRO is scheduled to launch GSAT-11, the “heaviest” satellite built by it, on-board Ariane-5 rocket of Arianespace from French Guiana on December 5. Weighing about 5,854 kg, GSAT-11 would play a vital role in providing broadband services across the country, and also provide a platform to demonstrate new generation applications, the Indian Space Research Organisation (ISRO) said. It is the “heaviest” satellite built by ISRO, the space agency said. GSAT-11 is the next generation “high throughput” communication satellite configured around ISRO’s  I-6K Bus, and it...
Post a Comment
Read more